The Trend of Cefepime-Induced Neurotoxicity: A Systematic Review

There has been increased use of cefepime due to concerns about the nephrotoxic effects combined vancomycin and Zosyn. However, is associated with neurotoxicity. We conducted a systematic review using online data explore trend cefepime-induced neurotoxicity over last 10 years. Forty-six articles met our inclusion criteria, including 73 cases noticed steady increase in reports neurotoxicity, from one case 2013 11 2022. Individuals aged 65 older accounted for most (52%). The top three indications administration included bone joint infections (25%), urinary tract (22.7%), pneumonia (22.7%). Most patients renal impairment have never had adjustment their dosage (either 2 g 12 hours day or eight day). occurred between days two five (n=29, 71%), while resolution 85%). While continues be popularly used effective antibiotic against gram-negative bacteria like Pseudomonas aeruginosa, its needs adjusted avoid